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4.85 out of 5

Specialties
Hand, Wrist & Elbow
Peripheral Nerve Surgery
G. Aman Luther, MD
Hand, Wrist & Elbow Center
Dr. Luther is a board-certified, fellowship-trained hand and upper extremity surgeon at Wake Orthopaedics. His clinical interest includes nerve injuries and reconstruction, peripheral nerve surgery, hand and upper extremity fractures, minimally invasive surgery, ligament and tendon disorders, rheumatoid and osteoarthritis, athletic injuries and pediatric hand surgery.
Over his career Dr. Luther has published over numerous peer-reviewed papers, book chapters, and lectured nationally and internationally on hand and upper extremity disorders. He is the recipient of numerous research and teaching awards and an active member of the American Academy of Orthopaedic Surgeons (AAOS) and American Society for Surgery of the Hand (ASSH). He currently serves on national committees focused on medical education and value-based healthcare delivery. He is actively involved in orthopedic product development and innovation. Throughout his career, he has focused on delivering exceptional patient care by combining his interests in education, research and clinical care.
- Medical School: University of Chicago, Chicago, IL
- Residency: Harvard Medical School, Boston, MA
- Fellowship: Harvard Hand Fellowship, Boston, MA
- Undergraduate: Massachusetts Institute of Technology (MIT), Cambridge, MA
Board Certifications
- Diplomate, American Board of Orthopaedic Surgeons
- 2023 NC Top Doctor Award
- 2022 NC Top Doctor Award
- Jun 2017 Best Clinical Research Award - Harvard Combined Orthopaedics Residency
- Jun 2016 Chief Resident - Massachusetts General Hospital/Harvard Combined Orthopaedics Residency
- Sep 2015 Clinician Scholar Development Program - America Academy of Orthopaedic Surgeons
- May 2015 Resident Teaching Award - Harvard Medical School
- Mar 2014 Best Poster Award - Adult Hip Reconstruction, American Academy of Orthopedic Surgeons Conference
- Oct 2013 Adrian E. Flatt Resident Research Scholarship - American Society of Surgery for the Hand
- May 2012 Leon Jacobson Award for Best Oral Presentation - Senior Scientific Session, University of Chicago Pritzker School of Medicine
- Apr 2012 Best Abstract - International Congress for Joint Reconstruction Conference
- Feb 2012 Best Oral Presentation - Tumor Society, American Academy of Orthopedic Surgeons
- Aug 2011 Fentress Research Fellowship - University of Chicago Pritzker School of Medicine
- Mar 2011 Best Basic Science Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine
- Mar 2011 Best Clinical Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine
- Jun 2010 Pritzker Research Fellowship - University of Chicago Pritzker School of Medicine
Research Publications
Luther G., Blazar P., Dyer G. Achieving Microsurgical Competency in Orthopedic Residents utilizing a Self-Directed Microvascular Training Curriculum. Journal of Bone and Joint Surgery. Feb 2019. PMID: 30730490
Luther G., Murthy, P., Blazar P. Cost of immediate surgery versus non-operative treatment for trigger finger in diabetic patients. Journal of Hand Surgery. Sep 2016. PMID: 27671766
Luther G., Miller P., Mahan S., Waters PM., Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). J Pediatric Orthopaedics. Sep 2016. PMID: 27636917
Luther G., Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. J Pediatric Orthopaedics. Apr 2015. PMID: 25887819
Luther G., Lamplot J., Chen X., Rames R., Wagner E., Shen J., Haydon R., He T.C., Luu H. IGFBP5 Domains Exert Distinct Inhibitory Effects on the Tumorigenicity and Metastasis of Human Osteosarcoma. Cancer Letters. May 2013. PMID 23665505
Luther G., Wagner E., Zhu G., Kang Q., Luo Q., Lamplot J., Bi Y., Luo X., Luo J., Teven C., Shi Q., Kim S., Gao J., Huang E., Rames R., Liu X., Li M., Hu N., Su Y., Chen L., He B.C., Zuo G., Deng Z., Reid R., Luu H., Haydon R., He T.C. BMP-9 Induced Osteogenic Differentiation of Mesenchymal Stem Cells: Molecular Mechanism and Therapeutic Potential. Current Gene Therapy. March 2011. PMID 21453282
Luther G., Rames R., Wagner E., Zhu G., Luo Q., Bi Y., Kim S., Gao J., Huang E., Yang K., Wang L., Liu X., Li M., Hu N., Su Y., Luo X., Chen L., Luo J., Haydon R., Luu H., Zhou L., He T.C. Molecular Basis of Differentiation Therapy for Soft Tissue Sarcomas. Trends in Cancer Research. Jan 2011.
Narayanan AS., Walley KC., Borenstein T., Luther GA., Jackson JB., Gonzalez TA. Surgical Strategies: Necrotizing Fasciitis of the Foot and Ankle Treated with Dermal Regeneration Matrix for Limb Salvage. Foot Ankle Int. Jan 2021
Ordikhani F., Zandi N., Mazaheri M., Luther G., Ghovvatoi M., Akbarzadeh A., Annabi N. Targeted Nanomedicines for the treatment of bone disease and regeneration. Medicinal Research Reviews. Dec 2020
Behzadi S., Luther G., Harris MB., Farokhzad O., Mahmoudi M. Nanomedicine for safe healing of bone trauma: Opportunities and challenges. Biomaterials. Sep 2017.
Lamplot J, Luther G., Mawdsley EL, Luu HH, Manning D. Modified Protocol Decreases Surgical Site Infections after Total Knee Arthroplasty. Journal of Knee Surgery. Mar 2015. PMID 25699629
Lamplot J., Liu B., Zhang W., Wang Z., Luther G., Wagner E., He T.C., Ho S. Reversibly immortalized articular chondrocytes acquire long-term proliferative capability while retaining chondrogenic phenotype. Cell Transplantation. Apr 2014. PMID 24800751
Chen X., Luther G., Zhang W., Nan G., Wagner E., Liao Z., Haydon R., Zhou L., Luu H., He T.C. The E-F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of human osteosarcoma cells. Cellular Physiology and Biochemistry. Sep 2013. PMID 24217649
Hekman K., Aliaga L., Straus D., Luther G., Chen J., Sampat., Frim D. Positive and negative predictors for good outcome after decompressive surgery for Chiari malformation type 1 as scored on the Chicago Chiari Outcome Scale. Neurological Research. Sep 2012. PMID 22781921
Aliaga L., Yassari R., Straus D., Hekman K., Luther G., Chen J., Sampat A., Frim D. A Novel Scoring System for Assessing Chiari Malformation Type 1 Treatment Outcomes. Neurosurgery. Mar 2012. PMID 21849925
Teven C., Liu X., Hu N., Tang N., Kim S., Huang E., Yang K., Li M., Gao J., Liu H., Luther G., Luo Q., Wang L., Rames R., Bi Y., Luo J., Luu H., Haydon R., Reid R., He T.C. Epigentic regulation of mesenchymal stem cells: A focus on osteogenic and adipogenic differentiation. Stem Cells and Nuclear Reprogramming. Jul 2011. PMID 21772852
Wagner E., Luther G., Zhu G., Luo Q., Shi Q., Kim S., Gao J., Huang E., Gao Y., Yang K., Wang L., Teven C., Luo X., Liu X., Li M., Hu N., Su Y., Bi Y., He B.C., Haydon R., Luu H., He T.C. Defective Osteogenic differentiation in the development of osteosarcoma. Sarcoma. Feb 2011. PMID 21437219
Pandey S., Luther G., Umanskiy K., Malhotra G., Rubin M., Hurst R., Fichera A. Minimally invasive pouch surgery for ulcerative colitis. Is there a benefit in staging? Diseases of the Colon and Rectum. Feb 2011. PMID 21304301
Rastegar F., Gao J., Shenaq D., Luo Q., Shi Q., Kim S., Jiang W., Wagner E., Huang E., Gao Y., Shen J., Yang K., He B.C., Chen L., Zuo G., Luo J., Luo X., Bi Y., Liu X., Li M., Hu N., Wang L., Luther G., Luu H., Haydon R., He T.C. Lysophosphatidic acid acyltransferase b (LPAATb) promotes tumor growth of human osteosarcoma. PLoS ONE. Dec 2010. PMID 21152068
He B.C., Gao J., Zhang B., Luo Q., Shi Q., Kim S., Huang E., Gao Y., Yang K., Wagner E., Wang L., Tang N., Luo J., Liu X., Li M., Bi., Shen J., Luther G., Hu N., Zhou Q., Luu H., Haydon R., Zhao Y., He T.C. Tetrandrine Inhibits Wnt/ β-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer. Molecular Pharmacology. Oct 2010. PMID 20978119
Teply B., Tong R., Jeong S., Luther G., Sherifi I., Yim C., Khademhosseini A., Farokhzad O., Langer R., Cheng J. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials. Dec 2007. PMID 18082254
Cheng J., Teply B., Sherifi I., Sung J., Luther G., Gu F., Nissenbaum E., Moreno A., Langer R., Farokhzad O. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials. Feb 2007. PMID 17055572
Podium Presentations
Luther G., Blazar P, Dyer, G. Effectiveness of a microvascular training curriculum utilizing nonliving models. Richard J. Smith Annual Research Symposium. April 2017.
Luther G., Miller P, Mahan, S, Waters PM, Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). Richard J. Smith Annual Research Symposium. May 2014.
Lamplot J., Luther G., Luu H., Manning D. Aseptic protocol decreases surgical site infections following hip arthroplasty. Mid-America Orthopaedic Association Annual Meeting. Apr 2014.
Lamplot J., Luther G., Krummenacher T., Hussain M., Luu H., Manning D. Aseptic protocol decreases surgical site infection after knee arthroplasty. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
Luther G., Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
Luther G., Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. Richard J. Smith Annual Research Symposium. May 2013.
Luther G., Stack M, Manning D. A novel aseptic protocol decreases surgical site infections following total hip and revision hip arthroplasty. International Congress for Joint Reconstruction (Apr 2012), MidAmerica Orthopaedics Association Annual Meeting (Apr 2012)
Luther G., Wagner E, Rames R., Lamplot J., Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference- Tumor Society Best Oral Presentation. Feb 2012.
Luther G., Rames R., Wagner E., Lamplot J., Haydon R., He T.C., Luu H. Mechanism of Osteosarcoma tumorigenesis by S100A4. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Feb 2012.
Luther G., Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. Huggins Research Symposium: Winner of Best Basic Science Presentation. Apr 2011.
Rames R, Luther G., Lamplot J, Wagner E, Luu H, He T.C. Induction of chondrogenic differentiation in Mesenchymal Stem Cells using a novel combination of Sox Transcription Factors and Bone Morphogenetic Proteins. Huggins Research Symposium: Winner of Best Clinical Presentation. Apr 2011.
Wagner E., Luther G., Haydon R., He T.C., Luu H. The mechanism underlying the inhibition of osteosarcoma tumorgenecity by IGFBP5. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Feb 2011.
Poster Presentations
Luther G., Jeffs A. Radial Sensory Nerve to AIN Transfer for Symptomatic RSN Neuromas. American Society for Surgery of the Hand (ASSH) Annual Conference. Aug 2022.
Luther G., Blazar P., Dyer G. Development of a low-cost, high-fidelity resident microsurgical training curriculum. American Society for Surgery of the Hand (ASSH) Annual Conference. Oct 2017.
Luther G., Murthy, P., Blazar P. Cost of immediate surgery versus non-operative treatment for trigger finger in diabetic patients. American Society for Surgery of the Hand (ASSH) Annual Conference. Oct 2016
Luther G., Miller P, Mahan, S, Waters PM, Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2015.
Lamplot J., Luther G., Borque K., Luu H.H., Manning D.W. Aseptic protocol decreases surgical site infection after hip arthroplasty. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
Luther G., Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. American Society for Surgery of the Hand (ASSH) Annual Conference. Oct 2013.
Lamplot J., Luther G., He T.C., Luu H. Methylation of IGFBP5 promoter regulates human osteosarcoma. Orthopaedic Research Society (ORS) Annual Conference. Jan 2013.
Luther G., Stack M, Rames R, Manning D. A novel aseptic protocol decreases surgical site infections following total hip and revision hip arthroplasty. International Congress of Joint Reconstruction. Apr 2012.
Luther G., Rames R., Wagner E., Haydon R., He T.C., Luu H. Inhibition of Osteosarcoma metastasis by Insulin Growth Factor Binding Protein 5 (IGFBP5). Orthopaedic Research Society (ORS) Annual Conference. Feb 2012.
Luther G., Rames R., Wagner E., Haydon R., He T.C., Luu H. Mechanism of Osteosarcoma tumorigenesis by S100A4. Orthopaedic Research Society (ORS) Annual Conference. Feb 2012.
Luther G., Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. American Society of Clinical Oncology (ASCO) Annual Conference. Jun 2011.
Luther G., Stack M, Manning D. Use of trabecular metal components in revision hip arthroplasty. Huggins Annual Research Symposium. Apr 2011.
Luther G., Stack M, Rames R, Manning D. Surgical site infections following total hip and revision hip arthroplasty. Huggins Annual Research Symposium. Apr 2011.
Luther G.Luther G, Wagner E, Rames R, Haydon R, He T.C., Luu H. S100A6 is a novel inducer of osteosarcoma tumorigenicity. Huggins Annual Research Symposium. Apr 2011.
Luther G.Luther G, Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. Huggins Annual Research Symposium. Apr 2011.
Rames R, Luther G., Lamplot J, Wagner E, Luu H, He T.C. Establishment and characterization of a novel murine chondrocytic cell line. Huggins Annual Research Symposium. Apr 2011.
Rames R, Luther G., Lamplot J, Wagner E, Luu H, He T.C. Induction of chondrogenic differentiation in Mesenchymal Stem Cells using a novel combination of Sox Transcription Factors and Bone Morphogenetic Proteins. Huggins Annual Research Symposium. Apr 2011.
Luther G.Luther G., Wagner E., Haydon R., He T.C., Luu H. Delineating the Role of S100A6 in Osteosarcoma and Osteogenic Differentiation. Orthopaedic Research Society (ORS) Annual Conference. Jan 2011.
Luther G.Luther G., Wagner E., Haydon R., He T.C., Luu H. The Mechanism Underlying the Inhibition of Osteosarcoma Tumorigenicity by IGFBP5. Orthopaedic Research Society (ORS) Annual Conference. Jan 2011.
The Star Ratings associated with each provider is the average of responses from the “likelihood to recommend” question on our patient experience surveys conducted by Qualtrics. The survey goes to patients seen in both the inpatient and outpatient setting; however, the surveys are different. The comments are actual comments received from patients. The number of responses received varies by provider.
September 2025 He cares
September 2025 I feel like Dr Luther is very knowledgeable in his field
September 2025 He’s a very nice physician and also very knowledgeable. I left with confidence in him to perform my upcoming surgery
September 2025 I’ve always been very well cared for
September 2025 He was very thorough and attentive to my needs
September 2025 The first surgery has healed well, second surgery seems to be going similarly well. Dr Luther is very patient explaining things, great bedside manner, very kind overall
August 2025 Dr. Luther is an asset to your team.
August 2025 Dr Luther is very open and genuinely interested in providing excellent patient care. The staff is very friendly and professional.
August 2025 Dr Luther was great - super friendly, explained things in a way that I couldceasily understand, provided options for treatment.
August 2025 Great experience
August 2025 Friendly and explained everything. Easy to understand and knowledgeable as he spoke.
August 2025 He is an excellent surgeon and very compassionate.
August 2025 My surgery with Dr. Luther was a success. All of the staff in orthopedics are kind, friendly, and.knowledgeable.
August 2025 Everybody there knows what they are doing and that makes me comfortable
August 2025 Dr. Luther is kind, professional and personable.
August 2025 Very nice and personable, understood the situation before even speaking
August 2025 Dr. Luther was outstanding! He explained everything thoroughly, answered my questions thoroughly and had a very pleasant demeanor.
August 2025 He is very approachable takes his time.
July 2025 Friendlly and very communicative
July 2025 Listened well and answered all questions and concerns. Very friendly
July 2025 very welcoming and provided the information in a manner that was understandable
July 2025 Dr explained course of treatment very well and In a caring manner
July 2025 Una exelente atracción y muy profesionales…
July 2025 Dr Luther has a great personality
June 2025 He is a very excellent hand surgeon and that speaks volumes.
June 2025 He is part of an incredible wakeed team that always makes e feel important and takes needs seriously
June 2025 Shows empathy
June 2025 Excellent surgeon and bedside manner
June 2025 Just an overall great experience with him as my physician
June 2025 Great surgeon, happy with the results. Attentive, caring and wants to help you gain function back and have the best life possible after the accident
June 2025 Treated me amazing
June 2025 Professional answer my questions & concerns in a way I understood.
June 2025 Excellent interaction with the doctor and staff. Impressive patient care. Helpful suggestions on how to proceed with the treatment.
May 2025 Professional, knowledgeable and compassionate Orthopaedic service!
May 2025 Great personality, very knowledgeable, all business no nonsense!
May 2025 He’s such a sweet man and truly cares about his patients.
May 2025 Fr. Luther very caring and understanding. He listens and explains in great detail.
May 2025 Excellent results and a thorough explanation of procedure
May 2025 Great listener and quick diagnosis. He is the best!
May 2025 I’m serious—I don’t even have the words to fully express it. Every single person I interacted with treated me with kindness and a smile. I truly felt valued and welcomed by each and every individual I met. I wanna give you big thank you.!!
April 2025 Dr. Luther explained in detail the problem cyst and artery position.
April 2025 Doctor was incredibly knowledgeable and didn't talk to me like a child. Very attentive and effective.
April 2025 Dr. Luther is friendly, knowledgeable and patient. Wonderful bedside manner. Takes time to answer questions and explain in understandable terms. He’s awesome!
April 2025 Very pleased with the Dr and staff
April 2025 Always excellent care
April 2025 Always caring
April 2025 The provider is fantastic and greatly influenced my rating.
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