CRI Leadership

WakeMed Clinical Research Institute (CRI) is structured to provide unsurpassed service, a collaborative environment and streamlined processes to deliver exceptional clinical study results for our valued clients. Our institute was created with insight into what constitutes an ideal clinical practice research program.

Led by a seasoned management team with more than four decades of clinical research experience, WakeMed CRI offers an ideal site for clinical research organizations seeking participants for pharmaceutical, biotech and medical device studies.

Experienced Leadership Team

WakeMed Clinical Research Institute’s leadership includes a Physician Oversight Council that includes knowledgeable investigators who have diverse backgrounds and represent a range of specialties:


Executive Sponsor

William Helton, MD

William Helton, MD, Cardiothoracic Surgery, Chief Medical Officer


Medical Director

Bill Lagarde, MD

Bill Lagarde, MD, FAAP, WakeMed Physician Practices - Pediatric Endocrinology

Administrative Staff

Diana Rhyne

Diana Rhyne, Director of Clinical Research

Aimee Williams

Aimee Williams, BSN, RN, CRC, Clinical Research Manager

Principal Investigators

Marc Silver, MD

Marc Silver, MD, Cardiology

Michael Soboeiro, MD

Michael Soboeiro, MD, Primary Care

Seth Brody, MD

Seth Brody, MD, OB/GYN


Contact Us

For more information on clinical research studies available at WakeMed Clinical Research Institute, please contact: Diana Rhyne (Director of Clinical Research) at DiRhyne@wakemed.org or Dr. Bill Lagarde (Medical Director) at BLagarde@wakemed.org