Join the discussion about health care issues in our nation and community on our blog, WakeMed Voices.

For Our Providers

Share/Save/Bookmark
Decrease (-) Restore Default Increase (+)

Tricyclic Crossreactivity Table

Tricyclic Antidepressents

 Compound  Conc.(ng/mL)  Effect
Amitriptyline 250 Positive
Amoxapine 100,000 Positive
Chlorpromazine 1300 Positive
Clomipramine 350 Positive
Cyclobenzaprine 400 Positive
Desimipramine 250 Positive
Doxepin 550 Positive
Imipramine 200 Positive
Nortriptyline (reference drug) 300 Positive
Trimipramine 300 Positive
2-Hydroxy-Imipramine 1700 Positive
 
Acetaminophen  1000  Negative 
Carbamazepine  100  Negative  
Dextromethorphan  1000  Negative  
Ethchlorvynol  500   Negative
Methaqualone  100   Negative 
Meperidine  100   Negative 
Perphenazine  0.4   Negative 
Phenobarbital  500   Negative 
Primidone  100   Negative 
Propoxyphene  500  Negative  
Secobarbital  500   Negative 
Amphetamine  500   Negative 
Cocaine  100   Negative 
Diazepam  100   Negative 
Maprotiline  Negative  
Methsuximide  100   Negative 
Morphine  100   Negative 
Phencyclidine  1000   Negative 
Phenytoin  100   Negative 
Promethazine  500   Negative
Trazodone  Negative  
Valproic acid 500 Negative
top of page     3/1/05

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Tricyclic compounds and other structurally related compounds were tested for cross reactivity in the assay.  The table lists the concentrations of the compounds that produce a positive result in the assay using 300 ng/mL nortriptyline as cut-off calibrator.