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Benzodiazepine Crossreactivity Table

 Compound  Conc. (ug/mL)  Effect

Oxazepam (reference drug)  

 0.2  

 Positive

Alprazolam    0.2   Positive
7-Aminoclonazepam   0.8  Positive
7-Aminoflunitrazepam  0.5  Positive
7-Aminonitrazepam    0.75   Positive
Bromazepam    0.3  Positive
Chlordiazepoxide    3.0   Positive
Clobazam    0.5    Positive
Clonazepam    0.3  Positive
Delorazepam    0.1   Positive
Desalkylflurazepam    0.1   Positive
N-Desmethylflunitrazepam  0.3 Positive
Diazepam    0.05  Positive
Flunitrazepam    0.2  Positive
Flurazepam    0.1  Positive
Halazepam    0.1   Positive
a-Hydroxy-alprazolam Glucuronide    1.5    Positive
Lorazepam    0.4  Positive
Lorazepam Glucuronide  250.0  Positive
Lormetazepam    0.2  Positive
Medazepam    0.2    Positive
Nitrazepam    0.3  Positive
Nordiazepam    0.05   Positive
Oxazepam Glucuronide  50.0  Positive
Prazepam  0.2  Positive
Temazepam    0.2   Positive
Temazepam Glucuronide  250.0  Positive
Triazolam    0.6   Positive
 
Acetaminophen    1000  Negative
Acetylsalicylic Acid    1000    Negative
Albuterol    1000    Negative
d-Amphetamine    1000    Negative
Caffeine    100    Negative 
Codeine    1000    Negative
Dextromethorphan    1000    Negative
Diphenhydramine    500    Negative
Doxepine    1    Negative
Hydroxyzine    40    Negative
Methadone    1000    Negative
Metronidazole  1000    Negative
Morphine    200    Negative
Oxaprozin  25    Negative
Pemoline  1000   Negative
Phencyclidine    1000    Negative
Promethazine    100    Negative
Propoxyphene    1000    Negative
Secobarbital    1000    Negative
Tramadol  1000  Negative
Trazadone    1000    Negative
Trimipramine    100    Negative
Trimethorim  1000 Negative
Zolpidem    100    Negative
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a) It is possible that other substances and/or factors (e.g., technical or procedural) not listed above may interfere with the test and cause false results.
b) Data shown was collected using SYNCHRON CX Systems. Equivalency between SYNCHRON LX Systems has been established by correlation analysis to SYNCHRON CX Systems.

Benzodiazepines are extensively metabolized. Metabolic and excretion rates differ among individuals; therefore, the levels of benzodiazepines and their respective metabolites in urine vary.